α-Defensins Promote Bacteroides Colonization on Mucosal Reservoir to Prevent Antibiotic-Induced Dysbiosis

Potential of lactoferrin to prevent antibiotic-induced Clostridium difficile infection

OBJECTIVES Clostridium difficile infection (CDI) is a global healthcare problem. Recent evidence suggests that the availability of iron may be important for C. difficile growth. This study evaluated the comparative effects of iron-depleted (1% Fe(3+) saturated) bovine apo-lactoferrin (apo-bLf) and iron-saturated (85% Fe(3+) saturated) bovine holo-lactoferrin (holo-bLf) in a human in vitro gut m...

Mucosal microbiome dysbiosis in gastric carcinogenesis.

OBJECTIVES We aimed to characterise the microbial changes associated with histological stages of gastric tumourigenesis. DESIGN We performed 16S rRNA gene analysis of gastric mucosal samples from 81 cases including superficial gastritis (SG), atrophic gastritis (AG), intestinal metaplasia (IM) and gastric cancer (GC) from Xi'an, China, to determine mucosal microbiome dysbiosis across stages o...

The use of prophylactic vancomycin to prevent MRSA colonization: Does this double-edged sword promote future

Enterobacteria of the neonate. Normal colonization and antibiotic-induced selection.

Enterobacterial digestive tract colonization of neonates under different conditions during their first days of life was studied. Our objective is to determine the frequency of antibiotic resistance under different conditions (hospitalized newborns treated or not with antibiotics, newborns in a maternity unit, mothers treated or not) thereby permitting a better appreciation of the role played by...

Comparing the effectiveness of broad spectrum antibiotic prophylaxis with single agent antibiotic prophylaxis to prevent post-cesarean section infection

Introduction: The rate of cesarean delivery is increasing. Infection is one of the most frequent and important complications of emergency cesarean section. Infection prophylaxis has an important role to reduce post-cesarean delivery complication. The aim of this study was to compare the effectiveness of broad spectrum antibiotic prophylaxis (Azithromycin+Cephalotin) with single agent antibiotic...